An Emerging Theme in Anti-Inflammatory Therapies

thousands of years ago with the use of readily available natural resources. It is only recently, however, that the cellular and molecular mechanisms of inflammation have been appreciated sufficiently to design anti-inflammatory strategies with limited side effects. For example, salicylates and glucocorticoids, two widely used anti-inflammatory drug classes, are now known to inhibit the activation of NFB, a transcription factor that regulates the inducible expression of a wide range of proinflammatory mediators. New generations of NFB–targeting anti-inflammatory agents that are specific, efficacious, and cost-effective may therefore complement or replace current therapies. In this review, we describe various classes of NFB inhibitors and discuss important unresolved issues regarding their use.